Allergy & Asthma Center, PC

Welcome

Allergy & Asthma Center, P.C., is an allergy practice based in Eugene, Corvallis, and Roseburg, Oregon.

Our practice includes allergists:

Appointments are available in the following locations in Oregon:

An allergist is a physician trained to diagnose, treat, and manage asthma and allergies, whether they are related to or caused by foods, environmental factors (such as pollen), drugs, or topical substances. Conditions that an allergist commonly treats include the following:

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For your information, each month we feature a topic of interest to our readers. Please read our current Topic of the Month below. To read previous articles that we have featured, please visit our Topic of the Month page.


December 2014 Topic of the Month

Overview

Systemic mastocytosis is a disorder where mast cells are abnormally increased in multiple organs, including the bone marrow. Mast cells are immune cells that produce a variety of mediators, such as histamine, that are important in the body’s allergic responses.

When mast cells are present in greatly increased numbers, the amount of released mediators can be very high and thereby cause multiple symptoms. The disease can occur in both children and adults.

Symptoms & Diagnosis

Initial signs of this disease may include “spots” that look like freckles on the skin of a person’s inner thighs or stomach. These spots are called urticaria pigmentosa and can transform into hives and itch if stroked or irritated or if the skin is exposed to sudden changes in temperature, such as a hot shower.

Other common symptoms include the following:

Diagnosis can include the following studies and should be conducted by a physician with special knowledge of this disorder:

Treatment & Management

The objective of treatment is to control the effects of mast cell-released mediators by avoidance of dietary and environmental triggers, as well as the use of various medications. Antihistamines are commonly used. Cromolyn sodium, ketotifen, and leukotriene-modifying agents are additional medications that may provide benefit. Epinephrine may be required to treat episodes of low blood pressure. More aggressive forms of Systemic Mastocytosis may require interferon or chemotherapeutic agents.

Reprinted with permission from the American Academy of Allergy Asthma & Immunology